"This report analyses recent trends and developments of the synthetic drugs market in East and South-East Asia and Oceania, comprising both amphetamine-type stimulants (ATS) and new psychoactive substances (NPS). NPS are substances of abuse that are not controlled by the International Drug Conventions but which may pose a public health threat. In this context, the term ‘new’ does not necessarily refer to new inventions but to substances that have recently become available.1 East and South-East Asia and Oceania has the largest ATS market in the world and in recent years the scope and availability of NPS has rapidly expanded. Moreover, this synthetic drugs market is becoming more complex and interconnected with other regions. These developments warrant an in-depth study to understand the current threat and impact of ATS and NPS in East and South-East Asia and Oceania within a global context. The analysis of the synthetic drug problem in the region is essential to complement the understanding of the illicit market for synthetic drugs called for in the 2009 Political Declaration and Plan of Action on International Cooperation towards an Integrated and Balanced Strategy to Counter the World Drug Problem. The availability of quality data and information-sharing in the region has improved with the support of the Drug Abuse Information Network for Asia and the Pacific (DAINAP), which offers a regional control mechanism for drug monitoring.2 However, the quality of data and information on some aspects of the synthetic drugs market remains limited. Particularly, demand-related data on the extent and pattern of use, and treatment remains scarce. And yet, methamphetamine and other synthetic drugs that pose a serious health threat to users seem to become increasingly available and are a challenge for health care providers and drug control authorities. Challenges in reducing the supply and demand for synthetic drugs Methamphetamine continues to dominate the synthetic drugs market in East and South-East Asia and is mainly available in two forms: methamphetamine tablets and crystalline methamphetamine. Increasing methamphetamine seizures and expert perception of high levels of methamphetamine tablet and crystalline methamphetamine use indicate the presence of a large and possibly expanding market in East and South-East Asia.3 For some years, the “ecstasy”4 market has been concentrated in parts of Oceania. Recently, according to expert perception, there is an emerging “ecstasy” market in parts of East and South-East Asia with use reported in Indonesia and countries in the Mekong sub-region.5 Addressing the trafficking of synthetic drugs in East and South-East Asia involves a number of difficulties. Over the last several years, countries in East and South-East Asia and Oceania have experienced rapid economic expansion. For instance, the share of the regions’ global Gross Domestic Product (GDP) based on purchasingpower-parity (PPP), is estimated to have increased from about 10 per cent in 2000 to over 30 per cent in 2014 at a value of more than US$ 28 trillion.6 Except for a sharp drop in 2009, exports and imports to and from countries in East and South-East Asia and Oceania have also significantly increased over the years. Between 2002 and 2013, imports and exports more than tripled to more than US$ 6.5 trillion and 6.9 US$ trillion respectively..."